论文部分内容阅读
目的 探讨重组人生长激素（ｒｈＧＨ）对老年消化道肿瘤患者术后蛋白分解代谢的影响，使用ｒｈＧＨ能否改善老年肿瘤患者 的免疫功能。方法患者２７例，分ｒｈＧＨ治疗组（ｎ＝１５）和对照组（ｎ＝１２），术后给予早期腹腔化疗（ＥＰＩＣ）和全胃肠外营养（ＴＰＮ）支持， ｒｈＧＨ组另在术后 １～６ ｄ上午皮下注射８ＩＵｒｈＧＨ。结果对照组术后 ５ ｄ、１０ ｄ的血清蛋白、前白蛋白、转铁蛋白和 ＩｇＧ、ＩｇＡ、ＩｇＭ、 ＣＤ３＋、ＣＤ４＋、ＣＤ８＋术后１０ ｄ较术前明显增加（Ｐ＜０．０１），精神状态明显好于对照组。术后１０ ｄ，对照组患者体重下降３～５ｋｇ，ｒｈＧＨ组下 降１～２ ｋｇ（Ｐ＜０．０１）。结论老年肿瘤患者在ＥＰＩＣ和ＴＰＮ营养支持的前提下应用ｒｈＧＨ能克服术后应激反应的蛋白分解代谢作用，改善宿主的免疫功能。
Objective To investigate the effect of recombinant human growth hormone (rhGH) on postoperative protein catabolism in elderly patients with digestive tract cancer and whether the use of rhGH can improve the immune function of elderly patients with cancer. Methods Twenty-seven patients were divided into two groups: rhGH treatment group (n=15) and control group (n=12). Patients received early intraperitoneal chemotherapy (EPIC) and total parenteral nutrition (TPN) support. rhGH group was followed by another postoperative one. The subcutaneous injection of 8IU rhGH was performed 6 days later. Results The levels of serum albumin, prealbumin, transferrin and IgG, IgA, IgM, CD3+, CD4+, and CD8+ in the control group increased significantly after surgery at 5 days and 10 days after operation (P<0.01). The mental state was significantly better than the control group. On the 10th day after surgery, the weight loss of patients in the control group was 3 to 5 kg, and that of the rhGH group was 1 to 2 kg (P<0.01). Conclusion The application of rhGH can overcome the catabolism of postoperative stress response and improve the immune function of the host in elderly patients with cancer under the precondition of nutritional support of EPIC and TPN.