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目的探讨二甲双胍对大鼠高脂饮食性脂肪肝的预防治疗作用。方法 36只SD大鼠随机分为6组:正常对照1、2组给予标准饲料;脂肪肝模型1、2组给予高脂饮食;预防组和治疗组分别在高脂饮食喂养3周、10周时加用二甲双胍100mg/(kg.d)灌胃7周。相对应的正常对照组和模型组同期给予等容积蒸馏水灌胃。分别在10周、17周后分批处死动物。结果预防组体重、肝指数、血清和肝脏甘油三酯(TC)、HOMA胰岛素抵抗指数(IR)和肝脂变程度均显著低于模型1组(P<0.05),与正常对照1组无显著差异(P>0.05);治疗组体重、肝指数、血清转氨酶、胰岛素、TG、肝脏TG、HOMA-IR和肝脂变程度均明显低于模型2组(P<0.05),但仍与正常对照2组有显著差异(P<0.05)。结论二甲双胍通过降脂和改善胰岛素敏感性,具有预防和治疗大鼠高脂饮食性脂肪肝的作用,但早期预防效果更佳。
Objective To investigate the preventive and therapeutic effects of metformin on fatty liver in rats with high-fat diet. Methods Thirty-six SD rats were randomly divided into 6 groups: normal control group 1 and 2 were given standard diet; fatty liver model group 1 and 2 were given high fat diet; preventive and treatment groups were fed with high fat diet for 3 weeks and 10 weeks When added with metformin 100mg / (kg.d) gavage for 7 weeks. Corresponding to the normal control group and model group given the same volume of distilled water during gavage. Animals were sacrificed in batches after 10 weeks and 17 weeks respectively. Results The levels of body weight, liver index, serum and liver triglyceride (TC), insulin resistance index (HOMA) and degree of hepatic steatosis in prevention group were significantly lower than those in model group 1 (P <0.05), but not in control group 1 (P> 0.05). The body weight, liver index, serum aminotransferase, insulin, TG, liver HOMA-IR and hepatic steatosis in the treatment group were significantly lower than those in the model group 2 (P <0.05) There was significant difference between the two groups (P <0.05). Conclusion Metformin can prevent and treat fatty liver of rats with high fat diet by lowering lipid and improving insulin sensitivity, but the prevention effect of metformin is better.