由于染色体研究技术的进展,特别是染色体高分辨技术的发展,使我们可以准确识别染色体异常综合征的重排断裂点,也可以识别恶性肿瘤染色体重排的断裂点。近年来,由于控制了培养条件,识别了一些脆性部位,其中,Xq27有显著的临床效应,常常伴发X连锁智力低下。有人认为,它可能是除先天愚型以外,导至智力低下的最重要的染色体异常。为了更好地认识这几类染色体的断裂点,本文介绍几次国际会议的资料,并试图 Due to advances in chromosomal research technology, especially the development of high-resolution chromosomes, we can accurately identify the rearrangement breakpoints of chromosomal abnormalities and also identify the breakpoints of chromosomal rearrangements in malignant tumors. In recent years, due to the control of the culture conditions, identify some brittle parts, of which, Xq27 has a significant clinical effect, often accompanied by X-linked mental retardation. Some people think that it may be the most important chromosomal abnormality leading to mental retardation except for idolatry. In order to better understand the breakpoints of these types of chromosomes, this article describes several international conferences and attempts