论文部分内容阅读
目的探讨不同糖尿病肾病分期的肾小球滤过率(GFR)的变化特点。方法实验组702例糖尿病患者,根据肾功能和尿白蛋白分为未诊断DN组(B组)、早期DN组(C组)、临床DN组(D组)和终末期DN组(E组),健康对照组62例(A组)。用改良的简化MDRD方程评估各组GFR并分析。结果(1)GFR变化特点为B组>C组>A组>D组>E组(P<0.05)。(2)与A组GFR相比,B组增加17.6%,C组增加11.8%,D组下降14.6%,E组下降65.9%。(3)GFR与DN分期呈负相关(r=-0.337,P<0.01)。结论DM患者在早期DN及其前期阶段GFR增加,进入临床期DN后GFR开始下降。以GFR作为DN分期依据,对终末期DN敏感,而对早期DN和临床期DN敏感性差。
Objective To investigate the changes of glomerular filtration rate (GFR) in different stages of diabetic nephropathy. Methods 702 diabetic patients were divided into two groups according to renal function and urinary albumin: DN group (group B), DN group (group C), DN group (group D) and DN group (group E) , 62 healthy control group (A group). GFRs of each group were evaluated and analyzed using a modified simplified MDRD equation. Results (1) The changes of GFR in group B> C group> A group> D group> E group (P <0.05). (2) Compared with GFR in group A, group B increased by 17.6%, group C increased by 11.8%, group D decreased by 14.6% and group E decreased by 65.9%. (3) GFR was negatively correlated with DN stage (r = -0.337, P <0.01). Conclusion The GFR in DM patients increases in the early stage of DN and its early stage. The GFR begins to decline after entering the clinical stage of DN. GFR as the basis for the classification of DN, end-stage DN sensitive, and early DN and clinical DN poor sensitivity.