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目的 :探讨高原肺水肿患者血浆内皮素 -1、一氧化氮含量变化及意义 ;方法 :对急进高原患高原肺水肿患者进行治疗前、治愈后血浆中内皮素 -1和一氧化氮含量测定 ,并与急进高原的健康人作对照研究 ;结果 :高原肺水肿患者血浆中内皮素 -1和一氧化氮含量在治疗前显著高于治愈后和对照组 (P <0 .0 1 ) ,且临床治愈后高原肺水肿患者血浆中内皮素 -1及一氧化氮含量仍高于正常对照组 (P <0 .0 5 ) ;结论 :内皮素 -1和一氧化氮参与了高原肺水肿的疾病过程。
Objective: To investigate the changes of plasma endothelin-1, nitric oxide and its significance in patients with high altitude pulmonary edema.METHODS: The levels of plasma endothelin-1 and nitric oxide were determined before and after treatment in patients with plateau pulmonary edema at high altitude, The results showed that the levels of ET-1 and NO in the plasma of patients with high altitude pulmonary edema were significantly higher than those in the control group and before treatment (P <0.01), and the clinical The plasma endothelin-1 and nitric oxide levels in patients with high altitude pulmonary edema after treatment were still higher than those in the normal control group (P0.05) .Conclusion: Endothelin-1 and nitric oxide are involved in the pathogenesis of high altitude pulmonary edema .