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目的:分析青岛市妇女儿童医院住院患儿EB病毒(EBV)感染情况及临床特征,为临床明确诊断、及时治疗提供依据。方法:采用化学发光免疫分析法定量检测480例住院患儿血清EBV VCA-Ig M、EA-Ig G、NA-Ig G含量。结果:480例住院患儿检出EBV抗体阳性385例,总阳性率为80.21%;血清中VCA-Ig M、EA-Ig G和NA-Ig G的检出率分别为15.21%、18.75%和66.46%,差异有统计学意义(P<0.05);不同年龄段患儿各抗体的检出率有所不同,近期感染的年龄段主要集中在0~3岁;EBV感染在性别上无差异(P>0.05);检测的385例EB抗体阳性的患儿中,以呼吸道感染最多[220例(57.14%)]。结论:此次研究住院患儿EBV感染率较高,不同年龄段患儿间EBV感染率不同,EBV感染在性别上无差异,EBV感染的相关疾病以呼吸道感染居首位。
Objective: To analyze the prevalence and clinical features of Epstein-Barr virus (EBV) inpatients in Qingdao Women and Children’s Hospital and provide the basis for clinical diagnosis and timely treatment. Methods: Quantitative detection of serum EBV VCA-Ig M, EA-Ig G and NA-Ig G in 480 hospitalized children by chemiluminescence immunoassay. Results: The positive rate of EBV antibodies in 480 inpatients was 385 and the positive rate was 80.21%. The positive rates of VCA-Ig M, EA-Ig G and NA-Ig G were 15.21%, 18.75% and 66.46%, the difference was statistically significant (P <0.05). The detection rate of each antibody in children of different age groups was different. The recent infection was mainly in the age group of 0-3 years. There was no gender difference in EBV infection P> 0.05). Of the 385 EB-positive children tested, respiratory infections were the highest (220 cases, 57.14%). Conclusion: In this study, the prevalence of EBV infection in hospitalized children was high, EBV infection rates varied among children of different ages, EBV infection had no gender differences, and EBV-related diseases were the most common respiratory tract infections.