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本文应用~(32)P标记HDVcDNA探针,用斑点杂交检测了176例乙型肝炎病人血清HDVRNA并同时检测了HBV血清标志物,结果25例(14.2％)HDVRNA阳性,提示四川地区是HDV感染高发区,在HDVRNA阳性的25例中,9例(36％)HBV复制标志阳性,明显低于RNA阴性组(72％,p<0.05),提示HDV在一定条件下抑制HBV的复制,部分抗-HBe阳性者HBV复制标志物亦阳性,提示这类病人可能有传染性,在各型肝炎中HDVRNA,HBVDNA的检出率无显著性差别。HDV的致病性及其与HBV致病性的关系有待进一步阐明。
In this paper, ~ (32) P labeled HDV cDNA probes were used to detect serum HDV RNA in 176 patients with hepatitis B by dot blot hybridization and serum HBV markers were also detected. Results HDV RNA was positive in 25 cases (14.2%), indicating HDV infection in Sichuan In the high incidence area, among the 25 cases of HDV RNA positive, 9 cases (36%) had positive HBV replication sign, which was significantly lower than that of RNA negative group (72%, p <0.05), suggesting that HDV could inhibit HBV replication under certain conditions. -HBe positive HBV replication markers are also positive, suggesting that such patients may be contagious, in the various types of hepatitis HDVRNA, HBVDNA detection rate was no significant difference. The pathogenicity of HDV and its relationship with the pathogenicity of HBV needs to be further elucidated.