Objective: To observe the clinical efficacy of acupuncture-moxibustion in treating Alzheimer’s disease(AD). Methods: Forty-eight eligible AD patients were enrolled to receive acupuncture plus herb-partitioned moxibustion. Mini-mental state examination(MMSE) was adopted for evaluation before and after intervention, and the therapeutic efficacy was observed. Results: After intervention, the MMSE score changed significantly(P<0.01), and the total effective rate was 83.3%. Conclusion: Acupuncture-moxibustion can significantly improve the cognitive function of AD patients, beneficial to the general promotion of the quality of life.