目的探讨慢性乙肝后肝硬化中医辨证分型与转化生长因子、肝纤维化血清血指标以及肝功能分级的相关性,为乙肝后肝硬化的辨证分型的客观化、标准化研究提供依据。方法观察乙肝后肝硬化患者各种证型之间及与健康者之间TGF-β1、透明质酸酶(HA)、层黏蛋白(LN)、Ⅳ型胶原蛋白(Ⅳ-C)、Ⅲ型胶原蛋白(PC-Ⅲ)。结果 TGF-β1、肝纤维化指标及肝功能分级与中医辨证分型密切相关。肝硬化各种证型之间与健康对照组之间比较,TGF-β1的值差别具有统计学意义(P<0.05)。肝肾阴虚证、瘀血内阻证组HA、PC-Ⅲ高于水湿内阻证、肝气郁结组(P<0.05),瘀血内阻证组HA、LN、Ⅳ-C、PC-Ⅲ组高于水湿内阻证、肝气郁结组,差异具有显著性(P<0.01)。结论 TGF-β1、肝纤维化指标可以作为乙肝后肝硬化的中医辨证中证型的量化指标,辨证论治指导临床用药。 Objective To investigate the correlation between TCM syndrome differentiation of chronic hepatitis B cirrhosis and transforming growth factor, serum and hepatic fibrosis serum markers and liver function classification, and to provide basis for objective and standardization of syndrome differentiation and classification of hepatitis B cirrhosis. Methods The levels of TGF-β1, HA, LN, Ⅳ-C and Ⅲ in patients with posthepatitic cirrhosis were observed. Collagen (PC-III). Results TGF-β1, liver fibrosis indicators and liver function classification and TCM syndrome differentiation are closely related. The difference of TGF-β1 between the various syndromes of cirrhosis and healthy control group was statistically significant (P <0.05). The levels of HA, PC-Ⅲ in liver-kidney-yin deficiency and blood stasis resistance syndrome group were higher than those in water-dampness internal resistance syndrome and liver qi stagnation group (P <0.05) Group Ⅲ was higher than water wet resistance syndrome, liver qi stagnation group, the difference was significant (P <0.01). Conclusion TGF-β1 and liver fibrosis indicators can be used as quantitative indicators of TCM syndrome differentiation and syndrome differentiation in patients with posthepatitic cirrhosis, syndrome differentiation and treatment guide clinical medication.