精原干细胞是具有终身有丝分裂能力进行自我复制同时也可分化成单倍体精子的生殖细胞。最近,一些研究发现精原干细胞可在体外被诱导成多能干细胞。提示精原干细胞可成为再生医学所需多能干细胞的很好来源,尤其是获得没有免疫排斥、患者自身来源的多能干细胞。本综述将重点介绍目前对精原干细胞多能性的认识及其在再生医学中应用的优势。 Spermatogonial stem cells are germ cells that have the capacity for lifelong mitosis to self-replicate and also differentiate into haploid spermatozoa. Recently, some studies have found that spermatogonial stem cells can be induced into pluripotent stem cells in vitro. These results suggest that spermatogonial stem cells may be a good source of pluripotent stem cells for regenerative medicine, especially for pluripotent stem cells derived from patients without their own immune rejection. This review will highlight the current understanding of the pluripotency of spermatogonial stem cells and their advantages in regenerative medicine.