论文部分内容阅读
目的探讨托拉塞米联合小剂量多巴胺治疗心衰合并肾功能不全患者的临床疗效。方法选取心衰合并肾功能不全患者120例,随机分为观察组与对照组,每组各60例。对照组给予常规治疗措施+托拉塞米,观察组在此基础上,再联合小剂量多巴胺治疗。比较两组治疗前、治疗4周的肾功能指标、脑钠肽(BNP)水平、心脏Tei指数及6min步行距离(6 MWT),比较两组不良反应情况。结果治疗后,两组BUN、SCr、BNP、Tei指数均降低,Ccr、Hb、ALB、6MWT均升高(t=3.35~7.52,P<0.05或P<0.01);且观察组BUN、SCr、BNP、Tei指数均低于对照组,Ccr、Hb、ALB、6MWT均高于对照组(t=3.21~5.10,P<0.05)。观察组与对照组不良反应发生率分别为12.07%、10.53%,差异无统计学意义(χ2=2.69,P>0.05)。结论托拉塞米联合小剂量多巴胺治疗心衰合并肾功能不全患者具有良好的临床疗效,有效改善了患者的心肾功能,且具有较好的安全性,这对其临床治疗具有一定的借鉴意义。
Objective To investigate the clinical efficacy of torsemide in combination with low-dose dopamine in patients with heart failure and renal insufficiency. Methods 120 patients with heart failure complicated with renal insufficiency were randomly divided into observation group and control group with 60 cases in each group. Control group was given conventional treatment + torsemide, the observation group on this basis, combined with low-dose dopamine treatment. The renal function, BNP level, heart Tei index and 6MWT distance before and 4 weeks of treatment were compared between the two groups. The adverse reactions were compared between the two groups. Results After treatment, the BUN, SCr, BNP and Tei index decreased, Ccr, Hb, ALB and 6MWT increased (t = 3.35-7.52, P <0.05 or P <0.01) BNP, Tei index were lower than the control group, Ccr, Hb, ALB, 6MWT were higher than the control group (t = 3.21 ~ 5.10, P <0.05). Adverse reactions in observation group and control group were 12.07% and 10.53%, respectively, with no significant difference (χ2 = 2.69, P> 0.05). Conclusion Torasemide combined with low-dose dopamine in patients with heart failure complicated with renal insufficiency has good clinical curative effect, effectively improves the patient’s heart and kidney function, and has good safety, which has some reference value for clinical treatment .