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目的:研究紫草素的大鼠在体肠吸收机制。方法:采用单向灌流模型,紫外分光光度法测定在体肠灌流紫草素的浓度变化,研究紫草素的吸收部位和吸收动力学特征。结果:紫草素在大鼠各肠段的吸收速率常数(Ka)、有效渗透系数(Papp)是结肠>空肠>十二指肠>回肠,且各肠段的Ka和Papp值均无显著性差异;灌流液中不同浓度紫草素的Ka,Papp均无统计差异。结论:紫草素在全肠道有不同程度的吸收,其中结肠吸收最好,药物浓度对紫草素的Papp和Ka值无影响,其吸收机制为被动扩散。
Objective: To study shikonin in rats intestinal absorption mechanism. Methods: The concentration of shikonin in peritoneal perfusion was determined by UV spectrophotometry using unidirectional perfusion model. The absorption site and absorption kinetics of shikonin were studied. Results: The absorption rate constant (Ka) and the effective permeability coefficient (Papp) of shikonin in each segment of the intestine were in the order of colon> jejunum> duodenum> ileum, and there was no significant difference in the Ka and Papp values Differences; different concentrations of shikonin in the perfusate Ka, Papp no statistical difference. CONCLUSION: Shikonin has different degrees of absorption in the whole intestine, of which the colonic absorption is the best. The drug concentration has no effect on the Papp and Ka values of shikonin, and its absorption mechanism is passive diffusion.