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目的初步探讨p53基因突变在鼻腔鼻窦肿瘤发生过程中的作用。方法采用免疫组织化学方法对58例鼻腔鼻窦肿瘤标本进行p53基因产物检测。结果24例内翻性乳头状瘤(IP)中未见阳性p53蛋白;25例恶性肿瘤和9例IP伴鳞状上皮不典型增生中p53蛋白阳性率分别为56%和44.5%,经统计学处理,二组间p53蛋白阳性率无统计学差异,二组对比IP的p53蛋白阳性率有显著性差异(P<0.01);恶性肿瘤中不同性别、吸烟嗜好、癌症发生类型及鳞癌病理分化程度的p53蛋白表达阳性率间差异无显著性(P>0.05)。结论p53基因突变与鼻腔鼻窦恶性肿瘤的发生关系密切,与IP发生可能无关。
Objective To investigate the role of p53 gene mutation in the pathogenesis of nasal sinus cancer. Methods Immunohistochemistry was used to detect p53 gene in 58 cases of nasal sinus tumors. Results No positive p53 protein was found in 24 cases of inverted papilloma (IP). The positive rates of p53 protein in 25 cases of malignant tumor and 9 cases of IP with squamous epithelial dysplasia were 56% and 44.5%, respectively. According to statistics There was no significant difference in the positive rate of p53 protein between the two groups (P <0.01). There were significant differences in the positive rate of p53 protein between the two groups (P <0.01). The differences of gender, smoking preference, type of cancer and pathological differentiation of squamous cell carcinoma There was no significant difference in the positive rate of p53 protein (P> 0.05). Conclusion The mutation of p53 gene is closely related to the occurrence of nasal sinus cancer, which may not be related to the occurrence of IP.