论文部分内容阅读
1983年Shaw等首次报道用羟氨喹和吡喳酮联合治疗小鼠曼氏血吸虫病有协同作用,其用量分别小于单独用量的1/4,目前此方法已在非洲试用于临床。Pugh等的研究表明,羟氨喹7.5mg/kg加吡喹酮15mg/kg对曼氏血吸虫病和埃及血吸虫病均有效。本试验目的在于观察不同剂量联合用药的疗效。作者在津巴布韦Raffingora地区的3所学校中选取同时感染曼氏血吸虫和埃及血吸虫的儿童59名(虫卵计数:尿>50个/ml;粪>100个/g)。治疗前每人作全身体检、血常规、血液生化检查及尿、粪虫卵计数。然后
In 1983, Shaw et al. Reported for the first time that synergistic treatment of mice with Schistosoma mansoni in combination with hydroxyquramine and pyrazinone had a synergistic effect, which was less than 1/4 of the dosage alone. This method has been clinically tested in Africa at present. Pugh and other studies have shown that hydroxylamine quinine 7.5mg / kg plus praziquantel 15mg / kg of Schistosoma mansoni and schistosomiasis are effective. The purpose of this experiment is to observe the efficacy of different doses of combination therapy. The authors selected 59 children (egg count: urine> 50 / ml; feces> 100 / g) of children who were both infected with Schistosoma mansoni and schistosoma mansoni at three schools in Raffingora, Zimbabwe. Before treatment, each person for physical examination, blood, blood biochemical tests and urine, fecal eggs count. then