The vast potential of system health monitoring and condition based maintenance on mod commercial aircraft is being realized through the innovative use of Airplane Condition Monitoring System (ACMS) data. However there are few methods addressing the issues of failure prognostics and predictive maintenance for commercial aircraft Air Conditioning System (ACS). This study developed a Bayesian failure prognostics approach using ACMS data for predictive maintenance of ACS. First, a health index characterizing the ACS health state is inferred from a multiple sensor signals using a data driven method. Then a dynamic linear model is proposed to describe the degradation process for failure prognostics. Bayesian inference formulas are carried out for degradation estimation and prediction. The developed approach is applied on a passenger aircraft fleet with ACMS data recorded for one year. The analysis of the case study shows that the developed method can produce satisfactory prognostics results, where all the ACS failure precur-sors are identified in advance, and the relative errors for the failure time prediction made when just entering the degradation wing stage are less than 8%. This would allow operators to proactively plan future maintenance.