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目的：对肠炎宝合剂体外抑菌作用的研究，为其治疗溃疡性结肠炎提供依据。方法：考察肠炎宝合剂和复方黄连素对大肠杆菌和痢疾杆菌的最小抑菌浓度（MIC）和最小杀菌浓度（MBC）。结果：肠炎宝合剂对大肠杆菌和痢疾杆菌的MIC分别是152μg/ml和174μg/ml，MBC分别是332μg/ml和363μg/ml；复方黄连素片对大肠杆菌和痢疾杆菌的MIC分别是168μg/ml和172μg/ml，MBC分别是349μg/ml和351μg/ml。两药作用强度相近。结论：肠炎宝合剂具有明显的抑菌、杀菌作用。“,”Objective: To study the bacteriostasis of Chang Yan Bao Mixture to prove the bacteria inhibiting and kil ing effectiveness in vitro. Methods: Respectively detect the drug concentration of Chang Yan Bao Mixture and berberine to Escherichia coli and Shigel a dysenteriae. Compare the difference of the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) between the two therapeutic drugs. Results: To the Escherichia coli, the MIC and MBC of Chang Yan Bao Mixture is 152μg/ml and 332μg/ml. The MIC and MBC of Chang Yan Bao Mixture to Shigel a dysenteriae is 174μg/ml, 363μg/ml. Both of them are similar to results of berberine. Conclusion: Beside berberine, Chang Yan Bao Mixture is another effective bacteria inhibitor and kil er.