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冠状动脉粥样硬化、冠脉痉挛、冠脉内血栓形成是导致冠心病心绞痛、心肌梗塞发作的主要因素。虽然这些因素间紧密联系,但在不同的患者可能以某种为主。进而,何种原因又是促使这些因素发展的基础,迄今尚未完全明暸。新近,发现前列环素(PGI_2)和血栓素(TXA_2)是血管平滑肌张力、血小板凝集强有力的调节者并参于冠脉粥样硬化形成。这种作用无疑给冠心病的研究以极大的兴趣。国内中草药如葛根素虽对心血管系统有多种效应,但在是否影响心肌梗塞时PGI_2和TXA_2的释放,且是否反映心血管效应上,目前尚无报道。本文在这一方面进行了探讨。
Coronary atherosclerosis, coronary spasm, coronary thrombosis is the main factor leading to angina pectoris and myocardial infarction. Although these factors are closely linked, they may be predominantly different in different patients. Furthermore, what kind of reasons are the basis for the development of these factors has not yet been fully understood. Recently, prostacyclin (PGI_2) and thromboxane (TXA_2) were found to be potent regulators of vascular smooth muscle tone and platelet aggregation and participate in the formation of coronary atherosclerosis. This effect is undoubtedly of great interest in the study of coronary heart disease. Chinese herbal medicine, such as puerarin, has a variety of effects on the cardiovascular system, but whether it affects the release of PGI_2 and TXA_2 during myocardial infarction and whether it reflects cardiovascular effects has not been reported yet. This article explores this aspect.