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目的探讨转录因子7类似物-2(TCF7L2)基因rs12255372 G>T多态性与妊娠期糖尿病(GDM)发病风险的关系。方法截止2016年9月,检索NCBI Pub Med、中国知网(CNKI)及万方等数据库关于rs12255372多态性与GDM发病相关病例-对照研究。Stata12.0软件检测所纳入数据发表偏倚及异质性,以合并效应的OR及95%置信区间(95%CI)评估rs12255372位点与GDM的发病风险。结果依据纳入、排除标准,共9篇文献,包含5778例研究对象纳入本研究。Meta分析显示,与G基因型相比,T等位基因携带者GDM发病风险显著增高,整体合并效应的OR值及95%CI为1.28(1.16~1.40);以种族进行亚组分析,高加索人群合并效应的OR及95%CI为1.29(1.15~1.45),亚洲人群为1.25(1.05~1.48)。基因型分析显示,显性遗传模型下,rs12255372 G>T与GDM发病显著相关,与GG基因型相比,GT+TT基因型携带者GDM发病风险显著增高,整体合并效应的OR及95%CI为1.35(1.20~1.53),高加索人群为1.39(1.20~1.62),亚洲人群为1.28(1.04~1.58)。结论 TCF7L2rs12255372 G>T多态性与GDM发病密切相关,G(T突变可能增加妊娠期妇女GDM的发病风险。
Objective To investigate the relationship between rs12255372 G> T polymorphism of transcription factor 7 analog-2 (TCF7L2) gene and the risk of gestational diabetes mellitus (GDM). Methods By September 2016, we searched the NCBI Pub Med, CNKI and Wanfang databases for case-control study on the association of rs12255372 polymorphism with GDM. Stata12.0 software was used to detect data published bias and heterogeneity. The risk of rs12255372 locus and GDM was assessed using OR of combined effect and 95% confidence interval (95% CI). Results Based on inclusion and exclusion criteria, a total of 9 articles, including 5778 subjects, were included in this study. Meta-analysis showed that compared with genotype G, the risk of GDM was significantly higher in carriers of T allele. The OR of the overall combined effect and 95% CI was 1.28 (1.16-1.40). Subgroups were analyzed by ethnicity. The Caucasian population The combined effect of OR and 95% CI 1.29 (1.15 ~ 1.45), Asian population was 1.25 (1.05 ~ 1.48). Genotype analysis showed that rs12255372 G> T was significantly associated with the incidence of GDM in dominant genetic model. Compared with GG genotype, GT + TT genotype carriers significantly increased the risk of GDM, the overall combined effect of OR and 95% CI Was 1.35 (1.20-1.53), the Caucasian population was 1.39 (1.20-1.62), and the Asian population was 1.28 (1.04-1.58). Conclusion TCF7L2 rs12255372 G> T polymorphism is closely related to the pathogenesis of GDM. G (T mutation may increase the risk of GDM in pregnant women.