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目的探讨及研究血必净注射液预防胆囊癌患者术后感染的疗效及对患者免疫力的影响,以了解血必净注射液在该类患者术后的应用价值。方法选取2014年1月-2015年7月于医院行手术治疗的90例胆囊癌患者为研究对象,将患者随机分为对照组和观察组,每组各45例,对照组进行常规围术期治疗,观察组在对照组的基础上加用血必净注射液治疗,对两组手术患者的术后感染率、术前及术后3、7d时的细胞免疫及红细胞免疫指标进行比较;采用SPSS16.0软件对数据进行统计分析。结果观察组术后感染率为2.22%,低于对照组的20.00%,两组比较差异有统计学意义(P<0.05);术前两组患者的CD3+CD4+、CD8+、CD4+及CD3+差异均无统计学意义;而术后3d及7d观察组的CD3+CD4+、CD4+及CD3+均高于对照组,CD8+则低于对照组,差异均有统计学意义(P<0.05);术前两组患者红细胞免疫指标中的自然肿瘤红细胞花环率(NTER)、直向肿瘤红细胞花环率(DTER)、免疫黏附促进因子(FEER)及免疫黏附抑制因子(FEIR),差异均无统计学意义;而术后3d及7d观察组的NTER、DTER及FEER均高于对照组,FEIR则低于对照组,差异均有统计学意义(P<0.05)。结论血必净注射液可有效预防胆囊癌患者的术后感染,且对患者的免疫力也有积极的影响。
Objective To investigate and study the effect of Xuebijing injection in preventing postoperative infection in patients with gallbladder cancer and its influence on the patient’s immunity so as to understand the application value of Xuebijing injection in postoperative patients. Methods Ninety patients with gallbladder carcinoma who underwent surgical treatment from January 2014 to July 2015 in our hospital were selected as the study objects. The patients were randomly divided into control group and observation group, with 45 cases in each group. The control group underwent routine perioperative period The treatment group and the observation group were treated with Xuebijing injection on the basis of the control group, and the postoperative infection rate, the cellular immunity and erythrocyte immune index at 3 and 7 days before and after operation were compared between the two groups. SPSS16.0 software for statistical analysis of the data. Results The postoperative infection rate in the observation group was 2.22%, which was lower than that in the control group (20.00%) (P <0.05). The difference of CD3 +, CD4 +, CD8 +, CD4 + and CD3 + between two groups was statistically significant (P <0.05). The levels of CD3 + CD4 +, CD4 + and CD3 + in the observation group at 3d and 7d after operation were significantly higher than those in the control group (P <0.05) In patients with erythrocyte immune indexes, there were no significant differences in the values of NTE, DTER, FEER and FEIR, The NTER, DTER and FEER of the observation group after 3d and 7d were higher than those of the control group, and the FEIR was lower than that of the control group (P <0.05). Conclusion Xuebijing Injection can effectively prevent postoperative infection in patients with gallbladder cancer, and also have a positive effect on the patient’s immunity.