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背景:日本人群中高胆固醇血症的循证治疗因缺乏该人群中的直接证据而受到阻碍。本研究旨在评估来自西方国家人群的他汀类药物治疗证据是否也适于日本人群。方法:在此项前瞻性、随机、公开标记的盲法研究中,无冠心病或卒中病史的高胆固醇血症(总胆固醇水平5.69～6.98mmol/L)患者被随机分配接受单纯饮食治疗或饮食+普伐他汀10～20mg/d。
BACKGROUND: Evidence-based treatment of hypercholesterolemia in the Japanese population is hampered by the lack of direct evidence in this population. This study was designed to assess whether statin treatment evidence from Western populations is also appropriate for the Japanese population. METHODS: In this prospective, randomized, open-label blinded study, patients with hypercholesterolemia (total cholesterol level 5.69-6.98 mmol / L) without a history of coronary heart disease or stroke were randomized to receive either diet or diet + Pravastatin 10 ~ 20mg / d.