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目的:观察利生导产汤联合地诺前列酮在足月妊娠分娩患者催产中的效果。方法:将78例足月妊娠分娩患者随机分为2组各39例,对照组采取地诺前列酮催产,观察组则行利生导产汤联合地诺前列酮催产,比较2组临床疗效、不良反应、用药前后宫口开大速度、前列腺素E_(2α)(PGE_(2α))、内皮素-1(ET-1)水平及分娩结局。结果:总有效率观察组为94.9%,对照组为74.3%,2组比较,差异有统计学意义(P<0.05)。阴道分娩率、剖宫产率、胎儿窘迫发生率观察组分别为94.9%、5.1%、7.7%,对照组分别为74.3%、25.6%、30.8%,2组比较,差异均有统计学意义(P<0.05)。治疗后2组宫口开大速度、PGE_(2α)及ET-1水平均较治疗前明显上升(P<0.05);而2组组间比较,差异无统计学意义(P>0.05)。不良反应率观察组为2.6%,对照组为5.1%,2组比较,差异无统计学意义(P>0.05)。结论:利生导产汤联合地诺前列酮能明显促进宫颈成熟,显著提高阴道分娩率,降低胎儿窘迫发生率。
OBJECTIVE: To observe the effect of Lisheng Danyu Decoction and dinoprostone on oxytocin in term pregnancy delivery. Methods: 78 cases of term pregnancy delivery were randomly divided into two groups of 39 cases, the control group took dinoprostone oxytocin, the observation group was leeching lead soup combined with dirprofenone oxytocin, the clinical efficacy of the two groups were compared, poor The rate of cervix uteri opening, the level of prostaglandin E 2α (PGE 2α), the level of endothelin -1 (ET-1) and the delivery outcome were observed before and after treatment. Results: The total effective rate was 94.9% in the observation group and 74.3% in the control group. There was significant difference between the two groups (P <0.05). The incidences of vaginal delivery, cesarean section and fetal distress were 94.9%, 5.1% and 7.7% in the observation group and 74.3%, 25.6% and 30.8% in the control group respectively. There were significant differences between the two groups P <0.05). The velocity of cervix uteri, PGE 2α and ET-1 in two groups after treatment were significantly higher than those before treatment (P <0.05). There was no significant difference between the two groups (P> 0.05). Adverse reaction rate was 2.6% in the observation group and 5.1% in the control group. There was no significant difference between the two groups (P> 0.05). Conclusion: Lysoside-producing decoction combined with dinoprostone can significantly promote cervical maturation, significantly improve the vaginal delivery rate and reduce the incidence of fetal distress.