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既往认为骨骼和骨骼肌作为支持机体基本结构和参与运动的主要器官,接受神经和体液的调节。近年越来越多的研究证据表明骨骼和骨骼肌具有强大的分泌活性物质的功能,除能以旁/自分泌方式作用于自身外,尚能通过血液循环以远距分泌的方式调节机体能量代谢、炎症反应、内分泌稳态等。更有意义的是骨骼和骨骼肌所分泌的活性物质参与中心性肥胖、胰岛素抵抗、血脂紊乱、高血压和微白蛋白尿的发病,提示骨骼和骨骼肌的内分泌功能在代谢综合征发病中具有重要意义。
In the past, bones and skeletal muscles were considered as the main organs supporting the basic structure of the body and participating in exercise, and were subjected to the regulation of nerves and body fluids. In recent years, more and more research evidences indicate that bone and skeletal muscle possess powerful secreting active substances. In addition to being able to act on their own in a side / autocrine manner, they can regulate body energy metabolism through long-distance secretion through the blood circulation Inflammatory reaction, endocrine homeostasis and so on. More importantly, the active substances secreted by the skeletal and skeletal muscles are involved in the pathogenesis of central obesity, insulin resistance, dyslipidemia, hypertension and microalbuminuria, suggesting that the endocrine function of skeletal and skeletal muscles has a role in the pathogenesis of metabolic syndrome Significance.