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制备和表征了包埋Gd EDTA的脂质体 ,测定了 pH ,离子强度 ,缓冲液组成及温度对Gd EDTA脂质体的影响 ,比较了Gd EDTA脂质体和Gd EDTA被肿瘤细胞摄入的动力学曲线。结果表明 ,Gd EDTA脂质体在 37℃和生理条件下最稳定 ,肿瘤细胞摄入Gd EDTA脂质体速率是Gd EDTA的 8倍 ,而释放Gd的速率 ,Gd EDTA脂质体远远低于Gd EDTA ,这些结果提供了脂质体包埋Gd EDTA作为钆中子俘获治疗药物的可能性。
Gd EDTA-embedded liposomes were prepared and characterized. The effects of pH, ionic strength, buffer composition and temperature on Gd EDTA liposomes were measured, and the ingestion of Gd EDTA liposomes and Gd EDTA by tumor cells was compared. Kinetic curve. The results showed that Gd EDTA liposomes were most stable at 37°C and physiological conditions. The rate of ingestion of Gd EDTA liposomes by tumor cells was 8 times that of Gd EDTA, and the rate of release of Gd was much lower than that of Gd EDTA liposomes. Gd EDTA, these results provide the possibility of liposome-embedded Gd EDTA as a neutron capture therapy drug.