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目的:探讨自拟黄芪补肾活血汤联合西药治疗糖尿病肾病(DN)的临床疗效。方法:选取2015年1月至2017年1月柘城中医院80例糖尿病肾病患者,随机分为实施常规西药治疗的对照组和采用自拟黄芪补肾活血汤联合西药治疗的观察组,各40例,比较两组患者经治疗后的临床疗效。结果:观察组患者经治疗后空腹血糖(FBG)为(7.1±0.9)mmol·L~(-1),餐后2 h血糖(2 h PPG)为(10.87±1.4)mmol·L~(-1)、收缩压(SBP)为(130.5±9.0)mm Hg、舒张压(DBP)为(84.3±7.4)mm Hg、总胆固醇(TC)为(1.69±0.8)mmol·L~(-1),以上指标均优于对照组,组间比较,差异具有统计学意义(P<0.05)。结论:采用自拟黄芪补肾活血汤治疗糖尿病肾病,可有效降低血糖、血压,平稳尿蛋白水平,保护肾脏,提高临床疗效。
Objective: To investigate the clinical efficacy of self-made Astragalus Bushen Huoxue Decoction combined with western medicine in the treatment of diabetic nephropathy (DN). Methods: From January 2015 to January 2017, 80 patients with diabetic nephropathy in Tancheng Hospital were randomly divided into the control group receiving conventional Western medicine and the observation group receiving self-made Astragalus Bushen Huoxue Decoction combined with western medicine, 40 cases in each group. The clinical efficacy of the two groups after treatment was compared. Results: After treatment, the fasting blood glucose (FBG) was (7.1 ± 0.9) mmol·L -1 and the 2 h PPG was (10.87 ± 1.4) mmol·L ~ (- 1, the SBP was (130.5 ± 9.0) mm Hg, the DBP was (84.3 ± 7.4) mm Hg and the total cholesterol was (1.69 ± 0.8) mmol·L -1 , The above indexes were better than the control group, the difference between the groups was statistically significant (P <0.05). Conclusion: The self-made Astragalus Bushenhuoxue Decoction for the treatment of diabetic nephropathy can effectively reduce blood sugar, blood pressure, smooth urinary protein levels, protect the kidneys and improve clinical efficacy.