近些年来,越来越多的人关心肿瘤干细胞及其在肿瘤中的自我更新能力。OCT4作为POU转录因子家族的一员,被公认为是干细胞的标志物,其表达水平同时反应了肿瘤干细胞的成瘤能力,与肿瘤的恶性行为密切相关。许多研究显示OCT4在肿瘤组织及肿瘤细胞系中均有表达。本文就其在妇科肿瘤中的研究作一综述。 In recent years, more and more people are concerned about cancer stem cells and their self-renewal ability in tumors. As a member of the family of POU transcription factors, OCT4 is recognized as a marker of stem cells. Its expression level reflects the ability of tumor stem cells to become tumorigenic, which is closely related to the malignant behavior of tumors. Many studies have shown that OCT4 is expressed both in tumor tissues and tumor cell lines. This article reviews its research in gynecologic oncology.