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心肌梗塞预后主要与左室功能障碍程度而不是与心肌进行性缺血的程度有关。这类患者左室功能障碍严重度是室性心律失常的主要决定因素。扎莫特罗(xamoterol)为一心脏选择性β_1受体部分激动剂,其内源性异丙肾上腺素活性仅45％。它能改善静息和运动时左室功能;当交感神经张力高时,又有附加的β受体阻滞活性。 15例心肌梗塞伴轻、中度心力衰竭(心功能Ⅱ～Ⅲ级),平均年龄58岁。随机口服地高辛0.125 mg每日2次,或扎莫特罗200mg每日2次,治疗4周;停药2周后两药交换,再治疗4周。
The prognosis of myocardial infarction is mainly related to the degree of left ventricular dysfunction but not the extent of myocardial ischemic. The severity of left ventricular dysfunction in these patients is a major determinant of ventricular arrhythmias. Xamoterol is a cardiac selective beta 1 receptor partial agonist with endogenous isoproterenol activity of only 45%. It improves left ventricular function at rest and during exercise; when sympathetic tone is high, there is an additional beta-blocker activity. 15 cases of myocardial infarction with mild to moderate heart failure (heart function Ⅱ ~ Ⅲ grade), mean age 58 years. Random oral digoxin 0.125 mg twice daily, or Zamoeda 200mg twice daily for 4 weeks; withdrawal two weeks after the exchange of two drugs, and then treated for 4 weeks.