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本室对57例慢性腹泻患者肠道微生态的菌群变化作了初步探讨,现将结果与52例健康人的材料作了比较。实验中我们挑选肠道微生物群中具有代表性的需氧和厌氧菌10种做了定性和定量分析。健康人组10种细菌的检出率为94％～100％;病人组的检出率则为75％～96％。二组间“t”检验的结果:说明包括肠杆菌科,葡萄球菌,类杆菌、双歧杆菌、消化球菌和真杆菌属在内都表现有非常显著性差异(P<0.01),梭菌也有显著性差异(P<0.05)实验结果表明慢性腹泻患者的肠道微生物群发生了显著失调。本文从4个方面讨论了微生态失调发生的原因:1.慢性腹泻与肠道微生物群间的相互关系;2.慢性腹泻影响了肠道微生物群的生长、繁殖、以及它们的定植受阻;3.肠粘膜牯液丢失可使肠道微生物群发生紊乱;4.抗生素与肠道内微生物群的微生态失调有关。我们认为发生肠道微生物群失调时应尽快重建其间关系的平衡。治疗时不宜使用以抗生素为主的方案,而应尽可能地使用生物制剂,此外,还应减少肠道蠕动,避免肠粘膜粘液的大量排出。
The room of 57 cases of chronic diarrhea in patients with intestinal microflora microbial community made a preliminary study, the results and 52 healthy people were compared. In the experiment, we selected 10 representative aerobic and anaerobic bacteria in gut microbiota for qualitative and quantitative analysis. The detection rate of 10 kinds of bacteria in healthy people ranged from 94% to 100%, while the detection rate in patients was 75% to 96%. The results of the “t” test between the two groups showed that there was a very significant difference (P <0.01) among Clostridium, Staphylococcus, Bacteroides, Bifidobacterium, Peptococcus and Eubacterium, Significant differences (P <0.05) The results of the experiment showed that there was a significant imbalance in gut microflora in patients with chronic diarrhea. This article discusses in four aspects the causes of dysbiosis: 1. The relationship between chronic diarrhea and gut microbiota; 2. Chronic diarrhea affects the growth and reproduction of gut microbiota and their resistance to colonization; 3 Intestinal mucosal fluid loss can make intestinal microflora disorder; 4 antibiotics and intestinal microbiota microbial imbalance. We think that the balance of the relationship should be reestablished as soon as possible in the event of intestinal microflora imbalance. Treatment should not be used antibiotic-based programs, but as much as possible the use of biological agents, in addition, should also reduce intestinal peristalsis, to avoid the massive discharge of intestinal mucus.