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目的研究胆囊结石病基因在9号染色体的位置。方法用微卫星位点为遗传标记对12个胆囊结石病家系进行基因组扫描,用非参数分析软件GENEHUNTER和参数分析软件BATCHLINK进行连锁分析,寻找9号染色体上与胆囊结石病连锁的位点及区域。结果D9S1682的LOD值207,NPL值192,P=004。进行分层分析发现,血液甘油三酯升高组D9S1682的LOD值由207上升到240。结论9号染色体上存在胆囊结石病基因位点,该位点可能和伴高甘油三酯血症胆囊结石病有关。
Objective To study the location of gallstone disease on chromosome 9. Methods The microsatellite loci were used as genetic markers to screen the genomes of 12 gallstone gallstone pedigrees. GENEHUNTER and parametric analysis software BATCHLINK were used for linkage analysis to search for the loci and regions linked to gallstone disease on chromosome 9 . Results D9S1682 LOD 207, NPL 192, P = 004. Stratified analysis revealed that the LOD value of D9S1682 increased from 207 to 240 in the elevated blood triglyceride group. Conclusion There is a gallstone disease locus on chromosome 9, which may be related to hypertriglyceridemia gallstone disease.