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目的:总结分析长脉宽1 064 nm掺钕钇铝石榴石(Nd∶YAG)激光、595 nm脉冲染料激光(PDL)或两者联合治疗会阴部婴幼儿血管瘤临床疗效、不良反应及其影响疗效的有关因素。方法:应用长脉宽1 064 nm Nd∶YAG激光、脉冲染料激光或两者联合治疗会阴部婴幼儿血管瘤35例,治疗间隔4~8周。统计治疗效果并分析影响疗效的因素。结果:35例患儿,其中男3例、女32例,年龄40 d~2岁,皮损面积0.1~15 cm2。治疗有效率为100%,治疗次数1~5次。常见的不良反应为红肿和水疱,一般3~5 d内修复,其中2例出现糜烂及渗出,5例痊愈后皮肤质地有变化,2例遗留色素沉着,未见感染、瘢痕等其他不良反应。结论:长脉宽1 064 nm Nd∶YAG激光及595 nm脉冲染料激光治疗会阴部婴幼儿血管瘤安全有效,不良反应轻微,值得推广应用。
OBJECTIVE: To summarize the clinical effects, adverse reactions and their effects of long pulse width 1.064 nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, 595 nm pulsed dye laser (PDL) or both in the treatment of perineal infantile hemangiomas Effective factors. Methods: Long-pulse 1 064 nm Nd:YAG laser, pulsed dye laser or a combination of both were used to treat 35 infantile hemangiomas in the perineum. The treatment interval was 4 to 8 weeks. Statistical treatment effect and analysis of the factors that affect the efficacy. Results: 35 cases of children, including 3 males and 32 females, aged 40 d ~ 2 years old, skin lesions area of 0.1 ~ 15 cm2. Treatment efficiency of 100%, the number of treatment 1 to 5 times. Common adverse reactions are redness and blisters, usually within 3 to 5 days to repair, of which 2 cases of erosion and exudation, 5 cases of skin texture after recovery have changed, 2 cases left pigmentation, no infection, scar and other adverse reactions . CONCLUSION: Long-pulse 1 064 nm Nd:YAG laser and 595 nm pulsed dye laser are safe and effective for the treatment of infantile hemangioma in perineal area with slight adverse reactions, which is worthy of promotion and application.