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目的:了解抗菌药物专项整治活动期间武汉地区β-内酰胺复方制剂用药情况,为合理用药提供依据。方法:统计分析2011~2013年武汉地区32家医院β-内酰胺复方制剂的用药金额、用药频度和日均费用。结果:2011~2013年武汉地区32家医院β-内酰胺复方制剂的用药金额呈逐年增长趋势,特别是头孢菌素/酶抑制药的增长更为显著。三年中用药金额最高的药物是头孢哌酮/他唑巴坦,用药频度最高的是羟氨苄青霉素/克拉维酸钾。结论:通过抗菌药物专项整治活动,β-内酰胺复方制剂的品种、品规数得到控制,但用药量仍呈显著增长趋势。为了促进β-内酰胺复方制剂的合理应用,除了加强管理,还应充分发挥国家细菌耐药监测网的指导作用。
OBJECTIVE: To understand the use of β-lactam compound preparations in Wuhan during the special rectification activities of antimicrobial agents to provide basis for rational drug use. Methods: The amount of drug, the frequency of medication and the average daily cost of β-lactam compound in 32 hospitals in Wuhan from 2011 to 2013 were statistically analyzed. Results: From 2011 to 2013, the dosage of β-lactam compound preparations in 32 hospitals in Wuhan showed a year by year increase trend, especially the growth of cephalosporin / enzyme inhibitor was more significant. Cefoperazone / tazobactam is the most expensive drug in three years, and amoxicillin / clavulanate potassium is most frequently used. Conclusion: Through the special rectification activities of antimicrobial agents, the varieties and product regulations of β-lactam compound preparations are controlled, but the dosage is still increasing significantly. In order to promote the rational use of β-lactam compound preparations, in addition to strengthening management, it is also necessary to give full play to the guiding role of the national bacterial resistance monitoring network.