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醋酸戈舍林(goserlin acetate),为一种用于晚期前列腺癌姑息疗法的植入剂,最近已获美国FDA批准使用。醋酸戈舍林与亮丙内酯(leuprolide)相类似,属于合成的十肽促黄体化激素—释放激素(LH-RH)同类物。戈舍林和亮丙内酯均具有在D.L—乳酸和羟基乙酸异分子聚合物中弥散的LH—RH同类物,每月可给病人用药一次。使用亮丙内酯,在增加1ml稀释液后就成为混悬液,用22号针头作肌内注射。戈舍林系用16
Goserlin acetate, an implants for palliative treatment of advanced prostate cancer, has recently been approved by the U.S. FDA. Goethrenol acetate is similar to leuprolide, and is a synthetic decapeptide luteinizing hormone-releasing hormone (LH-RH) congener. Gosearin and leuprolide both have LH-RH congeners dispersed in the D.L-lactic acid and glycolic acid polymers, administered to the patient once a month. Using leuprolide, a 1 ml dilution was added to make a suspension and a 22 gauge needle was used for intramuscular injection. Geshe Lin system with 16