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考察L 门冬酰胺酶前体脂质体 (L ASNasePL)与L ASNase对移植性小鼠急性淋巴细胞白血病的作用。采用DBA/ 2小鼠两种L12 10 、P3 88腹水瘤模型 ,脂质体组和L ASNase组小鼠每天ip一次 (按L 门冬酰胺酶计 740 0 ,370 0 ,185 0KU/kg) ,连续 10d。设生理盐水组 (0 9%NaCl,0 4ml/ 2 0 g)及阿霉素注射剂 (2mg/kg)组为阴性和阳性对照组。结果L ASNasePL及L 门冬酰胺酶 (L ASNase)皆能显著延长移植性淋巴细胞白血病的小鼠存活天数 (P <0 0 1) ,L ASNasePL对L12 10 、P3 88移植小鼠 ,生命延长率分别最高达 184 7%和 183 3%。L ASNase组生命延长率最高分别为 132 9%和 132 1%。L ASNasePL与相同剂量的L ASNase相比 ,其高、中剂量组 (740 0 ,370 0kU/kg)皆显著延长L12 10 、P3 88小鼠的存活天数 (P <0 0 5 )。
To investigate the effects of L-asparaginase liposome (L ASNasePL) and L ASNase on transplanted acute lymphoblastic leukemia in mice. Two L12 10 and P3 88 ascites tumor models were used in DBA / 2 mice. The mice in the liposome group and L ASNase group received ip once daily (as measured by L-asparaginase 7400, 3700, 1850 KU/kg). For 10 days. Let the normal saline group (0 9% NaCl, 0 4 ml/20 g) and adriamycin injection (2 mg/kg) group be negative and positive control groups. Results Both L ASNasePL and L-asparaginase (L ASNase) significantly prolonged the survival days of mice with transplantable lymphocytic leukemia (P < 0 01). L ASNasePL increased the survival rate of L12 10 and P3 88-transplanted mice. Up to 184 7% and 18 3 3%, respectively. The longest survival rate in the L ASNase group was 132 9% and 132 1%, respectively. L ASNasePL compared with the same dose of L ASNase, the high and middle dose group (740 0,370 0 kU/kg) all significantly prolonged the survival days of L12 10 and P3 88 mice (P <0 05).