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目的:研究赤土茯苓苷(Smi)对小鼠免疫功能的影响。方法:以左旋咪唑(Lev)为阳性对照组,观察Smi对小鼠的胸腺、脾脏指数、血清溶血素(HC50)、溶血空斑形成细胞数(PFC)、腹腔吞噬细胞吞噬中性红和超敏反应(DTH)的影响。结果:Smi使小鼠的胸腺、脾脏指数增加,其中剂量为30 mg/kg作用最显著(P<0.001)。Smi的各剂量组均使小鼠血清溶血素(HC50)和溶血空斑形成细胞数(PFC)明显增加(P<0.001);能增加小鼠腹腔吞噬细胞吞噬中性红的能力。Smi对由二硝基氯苯诱发的迟发型超敏反应(DTH)有明显的抑制作用(P <0.001)。结论:Smi能增加小鼠非特异性免疫和体液免疫功能,可抑制小鼠的细胞免疫功能。
Objective: To study the effect of stilbine (Smi) on immune function in mice. METHODS: Levimazole (Lev) was used as a positive control group to observe the thymus and spleen index, serum hemolysin (HC50), hemolytic plaque forming cells (PFC), phagocytic necrosis, neutral red, and superphages of Smi in mice. The effect of DTH. RESULTS: Smi increased the thymus and spleen index of mice, with a dose of 30 mg/kg being the most significant (P<0.001). Each dose of Smi significantly increased serum hemolysin (HC50) and hemolytic plaque forming cell number (PFC) in mice (P<0.001), and increased the ability of peritoneal phagocytic cells to phagocytose neutral red in mice. Smi significantly inhibited delayed-type hypersensitivity (DTH) induced by dinitrochlorobenzene (P < 0.001). Conclusion: Smi can increase the non-specific immunity and humoral immune function in mice and inhibit the cellular immune function in mice.