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目的:观察氯丙咪嗪对成年大鼠睡眠觉醒周期的影响。方法:16只大鼠随机分为2组,行48 h连续多导睡眠描记,第24,36,48小时分别给2组大鼠注射等量氯丙咪嗪(20 mg/kg)和生理盐水。结果:与生理盐水组比较,氯丙咪嗪组大鼠快速眼球运动睡眠明显减少,而快速眼球运动睡眠潜伏期明显延长,且运动觉醒较少,安静觉醒增加。结论:氯丙咪嗪在抑制快速眼球运动睡眠的同时,可减少运动觉醒,延长安静觉醒。
Objective: To observe the effect of clomipramine on sleep waking cycle in adult rats. Methods: Sixteen rats were randomly divided into two groups. The rats were subjected to continuous polysomnography for 48 h. Two groups of rats were injected with equal amount of clomipramine (20 mg / kg) and normal saline . Results: Compared with the saline group, the rats in the clomipramine group showed a significant decrease in rapid eye movement and sleep latency, while the latency to rapid eye movement significantly prolonged, with less motor awakening and more quiet awakening. Conclusion: The clomipramine can restrain the rapid awakening of movement and prolong the quiet awakening while inhibiting the rapid eye movement sleep.