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目的研究探讨降钙素原(PCT)在鉴别自身免疫性疾病活动和合并全身性感染中的临床应用价值。方法 230例自身免疫性疾病患者,将其分为自身免疫性疾病活动组(130例)和自身免疫性疾病非活动合并全身性感染组(100例),所有患者均在入院后的24 h对其各项炎症指标[包括C反应蛋白(CRP)、血沉(ESR)、白细胞(WBC)、PCT]进行测定,比较不同组别患者之间的差异,同时对CRP、PCT诊断全身性感染的灵敏度、特异性、准确度进行比较。结果两组患者CRP、PCT检测水平比较差异有统计学意义(P<0.05)。且PCT诊断自身免疫性疾病非活动合并全身性感染的灵敏度、特异性、准确度均显著高于CRP,差异有统计学意义(P<0.05)。结论通过PCT水平的检测,可以对自身免疫性疾病活动期和合并全身性感染的情况进行鉴别,且与传统炎症指标相比,有良好的诊断灵敏度和特异性,准确度更高,颇具临床应用价值。
Objective To investigate the clinical value of procalcitonin (PCT) in the identification of autoimmune diseases and systemic infection. Methods A total of 230 patients with autoimmune diseases were divided into three groups: active autoimmune disease group (130 cases) and autoimmune diseases non-active combined systemic infection group (100 cases), all patients were at 24 h after admission The indexes of inflammation (including CRP, ESR, WBC and PCT) were measured to compare the differences among different groups and the sensitivity of CRP and PCT in diagnosing systemic infection , Specificity, accuracy of comparison. Results There were significant differences in CRP and PCT between the two groups (P <0.05). The sensitivity, specificity and accuracy of PCT in the diagnosis of autoimmune diseases with inactive systemic infection were significantly higher than those of CRP (P <0.05). Conclusion The detection of PCT level can identify the active phase of autoimmune diseases and systemic infection, and has good diagnostic sensitivity and specificity compared with the traditional inflammatory indicators, with higher accuracy and clinical application value.