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目的:探讨过敏性紫癜性肾炎(HSPN)患者病理分级与临床特点相关性。方法:选取2010年4月至2016年7月39例于深圳市第二人民医院经肾穿刺活检确诊为HSPN患者,按国际儿童肾脏病研究协作组(ISKDC)的分级分为I级组、II级组与Ⅲ+ Ⅳ级组;分析过敏性紫癜性患者病理分级与年龄、肾功能损害、尿蛋白水平、免疫荧光免疫球蛋白A(Ig A)分级、免疫荧光C3等临床及病理指标的相关性。采用卡方检验及相关性分析。结果:相关性分析结果提示,过HSPN患者病理分级与年龄(χ2=2.468,r=0.376,P=0.018),肾功能损害(χ~2=2.343,r=0.359,P=0.025),尿蛋白水平(χ~2=2.945,r=0.436,P=0.006),血尿素氮(BUN)(r=0.482,P=0.002),三酰甘油(TG)(r=0.474,P=0.002)及低密度脂蛋白(LDL–C)(r=0.491,P=0.002)呈正相关关系,与血免疫球蛋白G(Ig G)水平呈负相关关系(r=–0.346,P=0.033)。结论:HSPN患者病理分级与年龄、肾功能损害、24 h尿蛋白水平、BUN、TG、LDL–C、Ig G等具有密切相关,因而,临床上可以通过过敏性紫癜患者病理损伤程度来预测其临床表现及预后。
Objective: To investigate the correlation between pathological grade and clinical features in patients with allergic purpura nephritis (HSPN). Methods: From April 2010 to July 2016, 39 patients with HSPN diagnosed by renal biopsy in Shenzhen Second People’s Hospital were divided into group I, group II according to ISKDC classification Grade, and grade Ⅲ + Ⅳ. The correlations between pathological grade and age, renal dysfunction, urinary protein level, immunoglobulin immunoglobulin A (IgA) grade and immunofluorescence C3 were analyzed in patients with Henoch-Schonlein Purpura Sex. Using chi-square test and correlation analysis. Results: The results of correlation analysis suggested that the pathological grade and age of patients with HSPN (χ2 = 2.468, r = 0.376, P = 0.018), renal dysfunction (χ ~ 2 = 2.343, r = 0.359, (R = 0.482, P = 0.002), triglyceride (TG) (r = 0.474, P = 0.002) and low (R = 0.491, P = 0.002), but negatively correlated with Ig G (r = -0.346, P = 0.033). Conclusion: The pathological grade of HSPN patients is closely related to age, renal dysfunction, 24 h urinary protein level, BUN, TG, LDL-C, Ig G and so on, therefore, the degree of pathological damage in patients with HSPN can be predicted clinically Clinical manifestations and prognosis.