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目的探讨淋巴结转移度(LNR)及肿瘤N分期对新辅助化疗后肺癌患者生存质量及预后的影响。方法回顾性分析本院2006年1月-2013年12月行肺大部切除术并经病理确诊肺癌的患者110例,并进行随访。收集患者临床资料,采用线性回归模型探讨临床因素与患者生存质量的关系,采用Cox回归模型探讨LNR及肿瘤N分期与患者死亡的关系。结果 110例肺癌患者生存质量评分量表SF-36得分为58.9±10.7,在8个相关领域中,RE得分最高(63.9±12.4),BP得分最低(52.2±8.9);年龄、手术方式、LNR、N分期与患者生存质量明显相关(P<0.05);LNR、N分期、肿瘤侵犯深度是肺癌患者预后的独立危险因素(P<0.05),且LNR对肺癌患者的死亡预测价值更大,HR为12.9。结论 LNR、手术方式、肿瘤N分期、年龄皆为肺癌患者术后生存质量的重要影响因素,LNR对术后患者死亡的预测价值要优于肿瘤N分期。
Objective To investigate the effect of lymph node metastasis (LNR) and tumor N staging on the quality of life and prognosis of patients with lung cancer after neoadjuvant chemotherapy. Methods A retrospective analysis of our hospital from January 2006 to December 2013 line of lung cancer and pathologically confirmed 110 cases of lung cancer were followed up. The clinical data of patients were collected. The relationship between clinical factors and quality of life was analyzed by linear regression model. Cox regression model was used to investigate the relationship between LNR, tumor N stage and patient’s death. Results The score of SF-36 in 110 patients with lung cancer was 58.9 ± 10.7, the highest score was RE (63.9 ± 12.4) and the lowest was BP (52.2 ± 8.9) in 8 related fields. The age, operation mode, LNR (P <0.05). LNR, N stage and tumor invasion depth were independent prognostic factors for lung cancer patients (P <0.05), and LNR had a greater predictive value for mortality in patients with lung cancer, and HR Is 12.9. Conclusion LNR, operation method, tumor N stage and age are important influencing factors for postoperative quality of life of patients with lung cancer. LNR is superior to tumor N stage in prognosis of postoperative patients.