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目的：为了解食管癌患者外周血（Ｐｅｒｉｐｈｅｒａｌ Ｂｌｏｏｄ，ＰＢ）粘附分子ＣＤ４４ 水平的临床意义。方法：用流式细胞术检测５２ 例食管癌患者术前外周血中ＣＤ４４ 水平，进行临床病理分析并与１００ 例正常人外周血中ＣＤ４４ 作统计学比较。结果：正常人外周血中ＣＤ４４ ％ 为４６ ．１４ ±１ ．３４ ，正常人外周血中ＣＤ４４ ％ 与年龄、性别比较无统计学意义，５２ 例食管癌患者外周血中ＣＤ４４ ％ 与年龄、性别比较也无统计学意义。而中段食管癌患者、外生型、溃疡型、中分化、低分化、晚期或复发患者、淋巴结转移４ 个以上的、Ａ 型、Ｏ 型血患者的外周血中ＣＤ４４ ％ 水平均高于正常人（ Ｐ＜ ０ ．０５） 。结论：食管癌外周血中ＣＤ４４ ％ 升高可提示肿瘤复发或属于晚期患者。ＣＤ４４ ％ 水平越高，肿瘤分化程度越差。ＣＤ４４ ％ 升高与肿瘤大体类型有关，外生型和溃疡型较高。Ｏ 型血和Ａ 型血ＣＤ４４ ％ 较高。用流式细胞仪检测食管癌患者术前外周血中ＣＤ４４ 水平，可为临床提供判断患者预后的参考依据。
Objective: To understand the clinical significance of peripheral blood (PB) adhesion molecule CD44 levels in patients with esophageal cancer. METHODS: CD44 levels in peripheral blood of 52 patients with esophageal cancer were measured by flow cytometry. The clinical pathological analysis was performed and compared with CD44 in peripheral blood of 100 normal subjects. Results: CD44% in peripheral blood was 46 in normal subjects. 14 ±1 . 34, normal human peripheral blood CD44% compared with age, gender, no statistical significance, 52 cases of esophageal cancer patients in peripheral blood CD44% compared with age and gender were also not statistically significant. The median CD44% level in patients with middle esophageal cancer, exogenous, ulcerative, moderately differentiated, poorly differentiated, advanced or relapsed, lymph node metastasis, A, or type O blood was higher than normal. ( P < 0 .05). CONCLUSIONS: Elevated CD44% in peripheral blood of esophageal cancer may indicate tumor recurrence or late stage disease. The higher the CD44% level, the worse the degree of tumor differentiation. The increase in CD44% was associated with the general type of tumor, with higher exogenous and ulcerative types. Blood type O and type A blood CD44% were higher. The use of flow cytometry to detect preoperative CD44 levels in patients with esophageal cancer can provide a reference for the clinical prognosis.