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氯霉素已是近代临床普遍应用的抗生素之一,因其味极苦,虽作成胶囊,伹婴孩服用仍有困难。另外,氯霉素不易溶于水(常温下1克需400毫升水方能溶解),很难作成浓度高的溶液供注射用。虽有用其他溶媒或助溶剂作成注射剂者,但往往不够理想。琥珀酸氯霉素钠(Sodium chloramphenicol succinate)系氯霉素与琥珀酸结合而成的酯的钠盐,极易溶解于水,其水溶液在室温下可保存一个月。本品与体
Chloramphenicol is one of the commonly used clinical antibiotics in modern times. Because of its extremely bitter taste, chloramphenicol is difficult to take although it is made into capsules. In addition, chloramphenicol is not easily soluble in water (1 g at room temperature to dissolve 400 ml of water), it is difficult to make a high concentration of solution for injection. Although with other solvents or cosolvent injection, but often less than ideal. Sodium chloramphenicol succinate Sodium salt of chloramphenicol combined with succinic acid is very soluble in water and its aqueous solution can be stored for one month at room temperature. This product and body