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本文旨在研究铝吸附和非吸附白喉-破伤风类毒素(DT)加强免疫后的IgE应答情况及IgE与副反应之间的关系。 作者用双盲法随机将104名(男68,女36)10岁学龄儿童分为两组:一组51人,接种铝吸附DT;另一组53人,接种非吸附液体DT。104名儿童均于婴儿期接种过3×0.5ml的吸附DT。吸附DT含30Lf/ml白喉类毒素和7.5Lf/ml破伤风类毒素。于上臂外侧三角肌处深皮下接种。分别于接种前和接种4周后采血,用改良Phadebas RAST检测抗白喉和破伤风类毒素IgE,>0.1 Phadebas RAST单位(PRU)/ml者判为阳性。
The aim of this study was to investigate the IgE response following immunization with aluminum-adsorbed and non-adsorbed diphtheria-tetanus toxoid (DT) and the relationship between IgE and side effects. The authors randomly divided 104 (68, 36) 10-year-old school-age children into two groups using a double-blind method: one group of 51 with aluminum-adsorbed DT and the other group of 53 with non-sorbent liquid DT. 104 children were vaccinated in infancy 3 × 0.5ml adsorption DT. Adsorption DT contains 30 Lf / ml diphtheria toxoid and 7.5 Lf / ml tetanus toxoid. In the upper arm lateral deltoid subcutaneous inoculation. Blood samples were taken before inoculation and 4 weeks after vaccination, respectively, and were tested positive for anti-diphtheria and tetanus toxoid IgE,> 0.1 Phadebas RAST units (PRU) / ml using modified Phadebas RAST.