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目的:探讨拉米夫定对环孢素血药浓度的影响。方法:采用自身对照法,比较10只家兔服用拉米夫定前后环孢素血药浓度有无差异。结果:10只家兔服用拉米夫定前后环孢素血药浓度无统计学差异(P>0.05)。结论:拉米夫定对家兔体内环孢素血药浓度无显著影响。
Objective: To investigate the effect of lamivudine on cyclosporine blood concentration. Methods: The self-control method was used to compare the plasma concentrations of cyclosporine before and after taking lamivudine in 10 rabbits. Results: Before and after taking lamivudine in 10 rabbits, cyclosporine blood concentration had no significant difference (P> 0.05). Conclusion: Lamivudine has no significant effect on the plasma concentration of cyclosporine in rabbits.