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巨细胞病毒(CMV)是疱疹病毒之一,感染人和哺乳类,引起细胞及核增大,两者中有典型的嗜酸性A型包涵体。CMV有高度种属异性和细胞相关性(Cellassociation),靶细胞为上皮、淋巴细胞等。人CMV(HCMV)1956年分离出,可无症状感染,严重时导致失明、发育异常或死亡。HCMV能持久感染、潜伏及再活动,能通过胎盘。潜伏感染引起的细胞损伤可能是致癌过程。 人肿瘤病霉 一些RNA病毒和DNA病毒能致细胞癌变,使其形
The cytomegalovirus (CMV) is one of the herpes viruses that infects humans and mammals and causes the enlargement of cells and nuclei, both of which have typical eosinophilic A-type inclusion bodies. CMV is highly species-specific and cell-associated. The target cells are epithelial cells, lymphocytes, and the like. Human CMV (HCMV) was isolated in 1956 and can be asymptomatically infected, leading to blindness, developmental abnormalities, or death in severe cases. HCMV can be persistently infected, latent and reactivated and can pass through the placenta. Cell damage caused by latent infection may be a carcinogenic process. Human neoplasms Some RNA viruses and DNA viruses can cause cell cancer and make it