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目的探讨结直肠癌的临床病理特征和预后。方法应用SPSS10.0软件对1991年1月至2002年12月间经手术和病理确诊、且随访资料完整的1829例结直肠癌患者的临床资料进行统计分析,并通过Cox回归模型,确立影响预后的独立因素。结果1829例结直肠癌患者的平均生存时间为76.8个月,5年生存率56.9%。单因素分析结果显示年龄、出现症状的时间、肿瘤部位、手术性质、病理类型、肿瘤直径、原发肿瘤侵犯深度、淋巴结转移、远处转移和Dukes分期与预后相关。多因素回归分析显示肿瘤部位、手术性质、病理类型、肿瘤直径、原发肿瘤侵犯深度、淋巴结转移和Dukes分期是影响结直肠癌患者术后生存的独立因素。结论应加强普查和早诊的意识,早期发现、早期诊断和治疗结直肠癌,最大限度地改善患者的生存状况。
Objective To investigate the clinicopathological features and prognosis of colorectal cancer. Methods The clinical data of 1829 patients with colorectal cancer diagnosed by operation and pathology from January 1991 to December 2002 were analyzed by SPSS10.0 software. The prognosis was determined by Cox regression model The independent factor. Results The average survival time of 1829 patients with colorectal cancer was 76.8 months and the 5-year survival rate was 56.9%. Univariate analysis showed that age, time to symptoms, location of tumor, nature of surgery, pathological type, tumor diameter, depth of primary tumor invasion, lymph node metastasis, distant metastasis and Dukes stage correlated with prognosis. Multivariate regression analysis showed that the location of the tumor, the nature of the operation, the pathological type, the diameter of the tumor, the depth of the primary tumor invasion, the lymph node metastasis and the Dukes stage were the independent factors influencing the postoperative survival in patients with colorectal cancer. Conclusion The awareness of census and early diagnosis should be strengthened, early detection, early diagnosis and treatment of colorectal cancer should be strengthened to maximize the survival of patients.