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目的 了解国产硝酸毛果芸香碱治疗精神药物所致口干的疗效和不良反应。方法 精神药物所致口干60例,分为两组,两组均为男女病人各15例,采用随机双盲对照方法分别给予硝酸毛果芸香碱片(2.5 mg/片)或外形相同的安慰剂片(淀粉)2片口服。一日三次,连用28天。结果 国产硝酸毛果芸香碱总有效率为73.3％,安慰剂组自然有效率为26.7％;组间比较,P<0.01。不良反应有窦缓,出汗和流泪。结论 本药对于精神药物所致口干,安全有效。
Objective To understand the efficacy and side effects of domestic pilocarpine nitrate in the treatment of dry mouth caused by psychotropic drugs. Methods Sixty patients with dry mouth caused by psychotropic drugs were divided into two groups. The two groups were 15 male and female patients respectively. The patients were given pilocarpine nitrate tablets (2.5 mg / tablet) or placebo tablets Starch) 2 tablets orally. Three times a day, once every 28 days. Results The total effective rate of domestic pilocarpine nitrate was 73.3%, and the natural effective rate in placebo group was 26.7%. There was significant difference between the two groups (P <0.01). Adverse reactions have slow sinus, sweating and tearing. Conclusion This medicine is safe and effective for dry mouth caused by psychotropic drugs.