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本文采用３２Ｋｇ重物挤压家兔双后肢的大腿和臀部５小时，复制出挤压伤的动物模型，在此基础上观察了解压后２４小时反映组织细胞损伤的血浆ＭＤＡ、ＮＡＧ及反映器官功能指标的血浆ＧＰＴ、肌酐、尿ＮＡＧ和肺通透指数变化，并分别用自由基清除剂ＣｏＱ１０和甘露醇于挤压前和解压前５分钟静脉注射，观察其对挤压伤的治疗作用。实验结果显示，挤压伤后血浆ＭＤＡ、ＮＡＧ显著性升高、心，肝、肺、肾、小肠和骨骼肌组织ＭＤＡ显著性增高，肝、肺、肾等器官功能明显降低，应用ＣｏＱ１０和甘露醇显示出减轻组织损伤保护器官功能的作用，但两者间没有明显差异。本文认为，ＣｏＱ１０和甘露醇可能通过抗自由甚途径对挤压伤后多器官功能损害起保护作用。
In this paper, 32Kg heavy objects were used to squeeze the thighs and buttocks of double hind limbs of rabbits for 5 hours to replicate the crush injury animal model. On the basis of this study, we observed the plasma MDA, NAG and organ function reflecting tissue injury 24 hours after decompression Indicators of plasma GPT, creatinine, urine NAG and pulmonary permeability index changes, and were scavenged with free radical scavenger CoQ10 and mannitol before compression and 5 minutes before decompression intravenous injection to observe the effect of crush injury. The results showed that MDA and NAG were significantly increased after crush injury, and MDA in heart, liver, lung, kidney, small intestine and skeletal muscle were significantly increased, and organs such as liver, lung and kidney were significantly reduced. CoQ10 and mannitol The alcohol showed the effect of lessening tissue damage in protecting organ function, but there was no significant difference between the two. This paper argues that CoQ10 and mannitol may have a protective effect on multiple organ dysfunction after crush injury by anti-free route.