目的 :本试验应用PI控制器自动化反馈控制罗库溴铵的输注 ,将肌松维持在恒定水平 ,通过确定罗库溴铵的稳态输注速率 ,来研究琥珀胆碱对罗库溴铵肌松作用的影响。方法 :选择 14例ASA分级Ⅰ～Ⅱ级的手术病人 ,随机分成对照组 (7例 )和试验组 (7例 )。对照组在麻醉诱导后 ,静注 0 6mg/kg罗库溴铵进行气管插管 ;试验组则静注1 5mg/kg琥珀胆碱后气管插管 ,待肌松作用完全恢复后 ,再静注 0 6mg/kg罗库溴铵。两组均在罗库溴铵静注给药后肌松恢复至TH为 5 %时 ,开始应用PI控制器自动化反馈控制罗库溴铵的持续输注。术中麻醉均采用N2 O 芬太尼静吸复合麻醉。结果 :罗库溴铵在琥珀胆碱完全恢复后给药的作用持续时间为 35± 8分钟 ,而单独给药为 2 4± 3分钟(P <0 0 5 ) ;罗库溴铵单独给药组维持 95 %神经肌肉阻滞的输注速率为 8 6± 1 1μg·kg-1·min-1,而在琥珀胆碱之后给药组为 4 2± 0 3μg·kg-1·min-1(P <0 0 1)。结论 :琥珀胆碱能够强化随后给药的罗库溴铵的肌松作用 OBJECTIVE: In this experiment, PI controller was used to control the infusion of rocuronium feedback automatically to maintain the muscle relaxant at a constant level. To determine the steady-state infusion rate of rocuronium, the effects of succinylcholine on rocuronium Effects of muscle relaxation. Methods: Fourteen patients with ASA grade Ⅰ ~ Ⅱ were randomly divided into control group (n = 7) and experimental group (n = 7). Control group after induction of anesthesia, intravenous injection of 0.6 mg / kg rocuronium tracheal intubation; experimental group was intravenous injection of 15mg / kg succinylcholine tracheal intubation until the complete recovery of muscle relaxant, and then intravenously 0 6 mg / kg rocuronium bromide. In both groups, when the muscle relaxant was restored to 5% TH after intravenous rocuronium administration, the PI controller was used to begin automatic feedback control of continuous infusion of rocuronium. Intraoperative anesthesia were used N2 O fentanyl inhalation anesthesia. RESULTS: The duration of rocuronium administration following complete recovery of succinylcholine was 35 ± 8 minutes compared with 24 ± 3 minutes for single administration (P <0 05); rocuronium alone The infusion rate of 95% neuromuscular block was 8 6 ± 1 1 μg · kg-1 · min-1 in the group and 42 ± 0 3 μg · kg-1 · min-1 in the administration group after succinylcholine (P <0 0 1). Conclusions: Succinylcholine is able to potentiate the muscle relaxant effect of the subsequent administration of rocuronium