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目的探讨中成药的不良反应情况。方法收集2012年3月至2014年3月广州市第一人民医院收治的84例出现中成药不良反应患者资料进行回顾性分析,对不同年龄患者不良反应分布情况、累及部位及临床表现、引发不良反应的中成药剂型及相关药物进行统计。结果≥61岁患者不良反应发生率最高,其次为51~60岁及≤10岁患者;84例患者中,不良反应累及皮肤所占比例最高,其次为胃肠道;引发患者不良反应的中成药剂型中,注射剂所占比例最高。结论中成药不良反应好发于大于51岁及小于10岁患者,主要累及皮肤,且以注射剂最多见,临床中需结合实际情况,合理使用中成药,减少不良反应发生,提高治疗安全性。
Objective To investigate the adverse reactions of proprietary Chinese medicines. Methods A retrospective analysis was performed on 84 patients with adverse reactions of Chinese patent medicine admitted to the First People’s Hospital of Guangzhou City from March 2012 to March 2014. The distribution of adverse reactions, location and clinical manifestations in patients of different ages were collected, The response of proprietary Chinese medicine formulations and related drugs statistics. Results The incidence of adverse reactions was highest in patients aged ≥61 years, followed by patients aged 51-60 years and ≤10 years. In 84 patients, the proportion of adverse reactions involved the skin was the highest, followed by the gastrointestinal tract. The proprietary Chinese medicines Formulation, the highest proportion of injections. Conclusions The adverse reactions of proprietary Chinese medicines occur in patients older than 51 and under 10 years old. They mainly involve the skin. Most of them are injections. The clinical application needs to be combined with the actual conditions to reduce the adverse reactions and improve the safety of treatment.