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目的探讨不同剂量佩尔地平对垂体后叶素诱发腹腔镜子宫肌瘤剔除术患者心血管反应的影响。方法择期行腹腔镜子宫肌瘤剔除术的患者60例,随机均分为四组。子宫肌瘤剔除前在腹腔镜监视下沿肌瘤周围肌层注入垂体后叶素6U,2min后,P1、P2、P3组分别静脉注射佩尔地平3、5、7μg/kg,C组静脉注射生理盐水5ml作为对照。记录注射垂体后叶素前1min(T0)、用药后30s(T1)、1min(T2)、2min(T3)、5min(T4)和25min(T5)时患者的MAP和HR。结果与T0时比较,T1、T2时四组MAP均降低,HR增快(P<0.05),T4、T5时C组MAP升高,HR减慢(P<0.05)。T4、T5时P1、P2、P3组MAP均低于C组,HR高于C组(P<0.05),且P1、P2组MAP高于P3组,HR低于P3组(P<0.05)。P1、P2、P3组发生低血压的例数分别为0、1、3例。结论静脉注射佩尔地平3μg/kg能有效预防局部注射垂体后叶素诱发腹腔镜子宫肌瘤剔除术患者的BP增高和HR减慢反应。
Objective To investigate the effect of different doses of perdipine on vasopressin-induced laparoscopic myomectomy patients with cardiovascular response. Methods Elective 60 cases of laparoscopic myomectomy patients were randomly divided into four groups. Uterine myomectomy before laparoscopic monitoring of pituitary fibroids around the pituitary injection of vasopressin 6U, 2min, P1, P2, P3 group were injected with Perdipine 3,5,7μg / kg, C intravenous group Saline 5ml as a control. The MAP and HR of patients at 1 minute (T0), 30 seconds (T1), 1 minute (T2), 2 minutes (T3), 5 minutes (T4) and 25 minutes (T5) were recorded before injection of pituitrin. Results Compared with T0, MAP decreased and HR increased at T1 and T2 (P <0.05). At T4 and T5, MAP increased and HR decreased (P <0.05). The MAP in P1, P2 and P3 groups were lower than those in C group at T4 and T5 (P <0.05), and the MAP in P1 and P2 groups were higher than that in P3 group (P <0.05). The incidence of hypotension in P1, P2 and P3 groups were 0, 1 and 3, respectively. Conclusion Intravenous injection of perdipine 3 μg / kg can effectively prevent BP elevation and HR slow response in patients with laparoscopic myomectomy induced by topical injection of pituitrin.