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目的:探讨多原发癌的病因、临床特点及其诊治。方法:回顾性总结分析了一组普通外科多原发癌病人的资料,并结合文献进行了分析。结果:本组77例多原发癌,占同期普通外科住院病人的1.33%(77/5768),半数以上发生于65岁及以上的老年人。胃肠道多原发癌占81.8%。其发生主要与下列因素有关:基因缺陷因素(遗传易感性)、环境因素、治疗所致(如放、化疗)、免疫缺陷、老龄。结论:多原发癌近年呈增加趋势,对于肿瘤病人的诊治,不要忽略了同时性癌的可能;手术仍是多原发癌实体瘤主要而有效的治疗手段。
Objective: To investigate the etiology, clinical features and diagnosis and treatment of multiple primary cancers. Methods: A retrospective analysis of a group of general surgical patients with multiple primary cancer information, combined with the literature were analyzed. Results: The group of 77 cases of primary cancer, accounting for the same period general surgical inpatients 1.33% (77/5768), more than half occurred in the elderly 65 years and older. Gastrointestinal multiple primary cancer accounted for 81.8%. Its occurrence is mainly related to the following factors: genetic defect factors (genetic susceptibility), environmental factors, treatment (such as radiotherapy and chemotherapy), immune deficiency, aging. Conclusion: Multiple primary cancers have been increasing in recent years. For the diagnosis and treatment of cancer patients, we should not neglect the possibility of simultaneous cancers. Surgery is still the main and effective treatment for multiple primary cancerous tumors.