结直肠癌的发病率和死亡率呈逐年上升的趋势,深入了解其发病机制对更好地进行靶向性治疗具有指导作用。为维持正常功能,哺乳动物肠黏膜需要经历一个连续的细胞更替过程,肠黏膜细胞增殖仅局限于隐窝,细胞分化则逐渐上移至绒毛,分化的肠细胞构成了肠黏膜细胞主体,最终发生程序性 The incidence and mortality of colorectal cancer are on the rise year by year, and an in-depth understanding of its pathogenesis has a guiding role in better targeted therapy. In order to maintain normal function, mammalian intestinal mucosa needs to undergo a continuous cell replacement process. Intestinal mucosal cell proliferation is limited to crypts, and cell differentiation gradually migrates to the villi. Differentiated intestinal cells constitute the main body of intestinal mucosa cells and eventually occur. Procedural